Recurrence of Focal Segmental Glomerulosclerosis (FSGS) in the Renal Allograft; an Update
نویسندگان
چکیده
FSGS is a histological description of the glomerular pathological findings; Clinically it is characterised by proteinuria, usually of nephrotic range, hypoalbuminaemia and variable degrees of renal impairment [1]. Sever nephrotic syndrome may increase the risk of thromboembolism [2]. FSGS is classified according to the aetiology into primary (idiopathic) and secondary. Secondary FSGS may be due to infection (like HIV and parvovirus B19), drugs and toxins (pamidronate toxicity and heroin), obesity, renal atheroembolic disease and reduced functioning renal mass with hyper filtration of the remaining nephrons [1].
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Recurrence of Focal Segmental Glomerulosclerosis (FSGS) in the Renal Allograft; an Update
Patients with primary focal segmental glomerulosclerosis (FSGS) have a high risk of disease recurrence post renal transplantation; this is usually characterised by significant proteinuria and associated with poor graft survival. FSGS recurrence is a challenging medical condition, not only because there is no recognised predictor of FSGS recurrence in the allograft, but also because there are no...
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